Light Sheet Microscopy Lightsheet - MesoSPIM (Irchel) Irchel Campus, Y44-J-33 The mesoSPIM (mesoscale selective plane illumination microscopy) is the ideal instrument to quickly bridge scales from the µm- to the cm-level, which enables it to serve as an excellent tool for detailed three-dimensional anatomical investigations in many biological and medical fields (Voigt et al., 2019). Lightsheet - Zeiss Z.1 (Irchel) The Zeiss Z.1 lightsheet microscope allows long term fluorescence imaging of large biological samples. It delivers thin optical sections with virtually no phototoxicity or bleaching and at very high temporal resolution.