Light Sheet Microscopy Lightsheet - MesoSPIM (Irchel) Irchel Campus, Y44-J-33 The mesoSPIM (mesoscale selective plane illumination microscopy) is the ideal instrument to quickly bridge scales from the µm- to the cm-level, which enables it to serve as an excellent tool for detailed three-dimensional anatomical investigations in many biological and medical fields (Voigt et al., 2019).